Research workbench
ISCTH4 transposase, strand transfer complex 1, STC1
Analyse ISCTH4 transposase, strand transfer complex 1, STC1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XGX
- Type
- protein + DNA
- Length
- 850 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mutator family transposase; DNA (47-mer); DNA (25-mer); DNA (21-mer)
- UniProt
- A3DBR0
- Pockets
- 16 · best druggability 0.82
Structure
x-ray diffraction · 5 distinct chains · 50% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mutator family transposase | protein | 402 | 49% helix, 15% strand | A3DBR0 |
| B | Mutator family transposase | protein | 355 | 51% helix, 14% strand | A3DBR0 |
| D | DNA (47-mer) | dna | 47 | — | — |
| E | DNA (25-mer) | dna | 25 | — | — |
| F | DNA (21-mer) | dna | 21 | — | — |
Pockets
16 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 717 | 0.82 | 0.86 | 67 | empty |
| 2 | 107 | 0.79 | 0.97 | 21 | empty |
| 3 | 252 | 0.75 | 0.88 | 56 | empty |
| 4 | 95 | 0.75 | 0.96 | 22 | empty |
| 5 | 307 | 0.68 | 0.83 | 30 | empty |
Interfaces
9 interfaces between chains.
- A–B · 2365 Ų buried · 19 hydrogen bonds · protein-protein
- A–D · 1387 Ų buried · 15 hydrogen bonds · protein-nucleic
- A–E · 1224 Ų buried · 25 hydrogen bonds · protein-nucleic
- D–E · 1078 Ų buried · 66 hydrogen bonds · nucleic-nucleic
- D–F · 876 Ų buried · 61 hydrogen bonds · nucleic-nucleic
Compared structures
- 6XGX · ISCth4 transposase, strand transfer complex 1, STC1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3DBR0
- Elsewhere: RCSB PDB 6XGX · PDBe 6XGX · UniProt A3DBR0
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