Research workbench
ISCTH4 transposase, pre-reaction complex, prc
Analyse ISCTH4 transposase, pre-reaction complex, prc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XGW
- Type
- protein + DNA
- Length
- 819 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mutator family transposase; DNA (32-mer)
- UniProt
- A3DBR0
- Pockets
- 15 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mutator family transposase | protein | 401 | 49% helix, 15% strand | A3DBR0 |
| B | Mutator family transposase | protein | 356 | 58% helix, 9% strand | A3DBR0 |
| D | DNA (32-mer) | dna | 31 | — | — |
| E | DNA (32-mer) | dna | 31 | — | — |
Pockets
15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.76 | 0.96 | 23 | empty |
| 2 | 735 | 0.73 | 0.79 | 65 | empty |
| 3 | 83 | 0.58 | 0.87 | 22 | empty |
| 4 | 244 | 0.54 | 0.77 | 28 | empty |
| 5 | 98 | 0.50 | 0.82 | 15 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2103 Ų buried · 16 hydrogen bonds · protein-protein
- D–E · 1380 Ų buried · 93 hydrogen bonds · nucleic-nucleic
- A–E · 1307 Ų buried · 27 hydrogen bonds · protein-nucleic
- A–D · 1208 Ų buried · 15 hydrogen bonds · protein-nucleic
- B–D · 355 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
- 6XGW · ISCth4 transposase, pre-reaction complex, PRC · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A3DBR0
- Elsewhere: RCSB PDB 6XGW · PDBe 6XGW · UniProt A3DBR0
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