Research workbench
Cryo-EM structure of a biotinylated SARS-cov-2 spike probe in the prefusion state (1 rbd up)
Analyse Cryo-EM structure of a biotinylated SARS-cov-2 spike probe in the prefusion… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6XF6
- Type
- protein
- Length
- 2,928 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spike glycoprotein
- UniProt
- P0DTC2
- Ligands
- NAG
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 3 distinct chains · 23% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spike glycoprotein | protein | 992 | 22% helix, 32% strand | P0DTC2 |
| B | Spike glycoprotein | protein | 945 | 23% helix, 33% strand | P0DTC2 |
| C | Spike glycoprotein | protein | 991 | 22% helix, 33% strand | P0DTC2 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 59 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 847 | 0.85 | 0.87 | 102 | empty |
| 2 | 582 | 0.84 | 0.89 | 67 | empty |
| 3 | 364 | 0.84 | 0.93 | 52 | empty |
| 4 | 286 | 0.77 | 0.89 | 34 | empty |
| 5 | 263 | 0.75 | 0.89 | 47 | empty |
Interfaces
3 interfaces between chains.
- A–C · 4832 Ų buried · 36 hydrogen bonds · protein-protein
- A–B · 4592 Ų buried · 35 hydrogen bonds · protein-protein
- B–C · 3898 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 47 glycan, 38 disulfide (N-glycosylation, disulfide).
Compared structures
- 6XF6 · Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (1 RBD… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DTC2
- Elsewhere: RCSB PDB 6XF6 · PDBe 6XF6 · UniProt P0DTC2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.