Research workbench
Interleukin-10 signaling complex with il-10RA and il-10RB
Analyse Interleukin-10 signaling complex with il-10RA and il-10RB in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6X93
- Type
- protein
- Length
- 1,042 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-10; Interleukin-10 receptor subunit alpha; Interleukin-10 receptor subunit…
- UniProt
- P22301, Q13651, Q08334
- Pockets
- 11 · best druggability 0.81
Structure
electron microscopy · 4 distinct chains · 34% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-10 | protein | 135 | 72% helix, 0% strand | P22301 |
| B, E | Interleukin-10 receptor subunit alpha | protein | 198 | 7% helix, 42% strand | Q13651 |
| C, F | Interleukin-10 receptor subunit beta | protein | 183 | 4% helix, 19% strand | Q08334 |
| D | Interleukin-10 | protein | 145 | 73% helix, 0% strand | P22301 |
Pockets
11 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1054 | 0.81 | 0.82 | 155 | empty |
| 2 | 932 | 0.79 | 0.82 | 131 | empty |
| 3 | 792 | 0.74 | 0.79 | 81 | empty |
| 4 | 304 | 0.72 | 0.85 | 36 | empty |
| 5 | 389 | 0.67 | 0.80 | 43 | empty |
Interfaces
9 interfaces between chains.
- A–D · 2611 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 1069 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 701 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 365 Ų buried · 3 hydrogen bonds · protein-protein
- D–F · 294 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6X93 · Interleukin-10 signaling complex with IL-10RA and IL-10RB · the same entry in another collection · chain F against F, TM-score 1.00
- Q13651 · AlphaFold monomer V2.0 prediction for interleukin-10 receptor subunit alpha (Q13651) · a predicted model of the same protein · chain B against A, TM-score 0.94
- P22301 · AlphaFold monomer V2.0 prediction for interleukin-10 (P22301) · a predicted model of the same protein · chain A against A, TM-score 0.87
- Q08334 · AlphaFold monomer V2.0 prediction for interleukin-10 receptor subunit beta (Q08334) · a predicted model of the same protein · chain C against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22301
- Every structure of UniProt Q13651
- Every structure of UniProt Q08334
- Elsewhere: RCSB PDB 6X93 · PDBe 6X93 · UniProt P22301 · UniProt Q13651 · UniProt Q08334
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