Research workbench
Structure of phis Fab (SC56-2) in complex with phis mimetic peptide
Analyse Structure of phis Fab (SC56-2) in complex with phis mimetic peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6X1W
- Type
- protein
- Length
- 441 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SC56-2 heavy chain; SC56-2 light chain; Aclyana-3-ptza peptide
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | SC56-2 heavy chain | protein | 215 | 6% helix, 49% strand | — |
| L | SC56-2 light chain | protein | 221 | 8% helix, 58% strand | — |
| A | Aclyana-3-ptza peptide | protein | 5 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 415 | 0.59 | 0.75 | 46 | empty |
| 2 | 56 | 0.51 | 0.87 | 21 | empty |
| 3 | 171 | 0.46 | 0.75 | 34 | empty |
| 4 | 57 | 0.28 | 0.74 | 16 | empty |
| 5 | 52 | 0.25 | 0.73 | 13 | empty |
Interfaces
3 interfaces between chains.
- H–L · 1885 Ų buried · 22 hydrogen bonds · protein-protein
- H–A · 233 Ų buried · 11 hydrogen bonds · protein-protein
- L–A · 227 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide, 2 modified (disulfide, cyclization, nonstandard).
Compared structures
- 6X1W · Structure of pHis Fab (SC56-2) in complex with pHis mimetic peptide · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6X1W · PDBe 6X1W
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