Research workbench
NUP133 (AA55-481) from S. cerevisiae bound by vhh-SAN5
Analyse NUP133 (AA55-481) from S. cerevisiae bound by vhh-SAN5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6X04
- Type
- protein
- Length
- 2,723 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoporin NUP133; Vhh-SAN5
- UniProt
- P36161
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 7 distinct chains · 4% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoporin NUP133 | protein | 367 | 5% helix, 49% strand | P36161 |
| B, D, F, H, J, L | Vhh-SAN5 | protein | 116 | 5% helix, 52% strand | — |
| C | Nucleoporin NUP133 | protein | 337 | 4% helix, 50% strand | P36161 |
| E | Nucleoporin NUP133 | protein | 315 | 4% helix, 54% strand | P36161 |
| G | Nucleoporin NUP133 | protein | 334 | 4% helix, 54% strand | P36161 |
| I | Nucleoporin NUP133 | protein | 346 | 3% helix, 52% strand | P36161 |
| K | Nucleoporin NUP133 | protein | 328 | 4% helix, 53% strand | P36161 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1127 | 0.79 | 0.81 | 116 | empty |
| 2 | 844 | 0.78 | 0.81 | 77 | empty |
| 3 | 783 | 0.78 | 0.82 | 85 | empty |
| 4 | 875 | 0.78 | 0.81 | 84 | empty |
| 5 | 952 | 0.78 | 0.80 | 102 | empty |
Interfaces
30 interfaces between chains.
- K–L · 796 Ų buried · 13 hydrogen bonds · protein-protein
- I–J · 782 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 766 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 763 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 736 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6X04 · Nup133 (aa55-481) from S. cerevisiae bound by VHH-SAN5 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36161
- Elsewhere: RCSB PDB 6X04 · PDBe 6X04 · UniProt P36161
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.