Research workbench
Crystal structure of anti-muscle specific kinase (musk) Fab, MUSK1B
Analyse Crystal structure of anti-muscle specific kinase (musk) Fab, MUSK1B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WYT
- Type
- protein
- Length
- 429 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MUSK1B heavy chain; MUSK1B light chain
- Ligands
- NAG
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | MUSK1B heavy chain | protein | 220 | 5% helix, 49% strand | — |
| L | MUSK1B light chain | protein | 209 | 8% helix, 51% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains L
- GOL · Glycerol · additive · 3 copies · chains H, L
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 579 | 0.63 | 0.75 | 59 | empty |
| 2 | 163 | 0.53 | 0.80 | 28 | empty |
| 3 | 82 | 0.40 | 0.78 | 17 | empty |
| 4 | 50 | 0.25 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- H–L · 1714 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 6WYT · Crystal structure of anti-Muscle Specific Kinase (MuSK) Fab, MuSK1B · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6WYT · PDBe 6WYT
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.