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Crystal structure of CA6-bound CARD1
Analyse Crystal structure of CA6-bound CARD1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WXY
- Type
- protein + RNA
- Length
- 750 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CA6; CARD1
- UniProt
- F2NWD3
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CA6 | rna | 6 | — | — |
| B, C | CARD1 | protein | 372 | 41% helix, 22% strand | F2NWD3 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 624 | 0.65 | 0.76 | 75 | empty |
| 2 | 362 | 0.57 | 0.75 | 46 | empty |
| 3 | 246 | 0.51 | 0.75 | 40 | empty |
| 4 | 56 | 0.26 | 0.72 | 11 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1585 Ų buried · 28 hydrogen bonds · protein-protein
- A–C · 600 Ų buried · 10 hydrogen bonds · protein-nucleic
- A–B · 578 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
- 6WXY · crystal structure of cA6-bound Card1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F2NWD3
- Elsewhere: RCSB PDB 6WXY · PDBe 6WXY · UniProt F2NWD3
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