Crystal structure of recombinant human acetylcholinesterase in complex with gd and hi-6

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• GD8 · (1R)-1,2,2-trimethylpropyl (S)-methylphosphinate · ligand · 2 copies · chains A, B
• HI6 · 4-(aminocarbonyl)-1-[({2-[(E)-(hydroxyimino)methyl]pyridinium-1-yl}methoxy)methyl]pyridinium · ligand · 2 copies · chains A, B
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A, B
• FUC · alpha-L-fucopyranose · sugar · 2 copies · chains A, B
• NO3 · Nitrate ion · ion · chains B
• EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
• PE8 · 3,6,9,12,15,18,21-heptaoxatricosane-1,23-diol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6WVO · Crystal Structure of Recombinant Human Acetylcholinesterase In Complex with GD and HI-6 · the same entry in another collection · chain A against A, TM-score 1.00
• P22303 · AlphaFold monomer V2.0 prediction for acetylcholinesterase (P22303) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P22303
• Elsewhere: RCSB PDB 6WVO · PDBe 6WVO · UniProt P22303