Research workbench
Mitochondrial SAM complex in lipid nanodiscs
Analyse Mitochondrial SAM complex in lipid nanodiscs in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WUH
- Type
- protein
- Length
- 1,037 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SAM35; BAC_SURFACE_AG domain-containing protein; TOM37 domain-containing protein
- UniProt
- G2QAT9, G2QFF9, G2Q6R7
- Pockets
- 14 · best druggability 0.81
Structure
electron microscopy · 3 distinct chains · 30% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SAM35 | protein | 308 | 40% helix, 5% strand | G2QAT9 |
| B | BAC_SURFACE_AG domain-containing protein | protein | 435 | 10% helix, 22% strand | G2QFF9 |
| C | TOM37 domain-containing protein | protein | 294 | 50% helix, 4% strand | G2Q6R7 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 373 | 0.81 | 0.90 | 67 | empty |
| 2 | 802 | 0.75 | 0.80 | 83 | empty |
| 3 | 990 | 0.71 | 0.75 | 77 | empty |
| 4 | 136 | 0.69 | 0.90 | 28 | empty |
| 5 | 349 | 0.64 | 0.80 | 37 | empty |
Interfaces
2 interfaces between chains.
- A–B · 2043 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 1725 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 6WUH · Mitochondrial SAM complex in lipid nanodiscs · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G2QAT9
- Every structure of UniProt G2QFF9
- Every structure of UniProt G2Q6R7
- Elsewhere: RCSB PDB 6WUH · PDBe 6WUH · UniProt G2QAT9 · UniProt G2QFF9 · UniProt G2Q6R7
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