Research workbench
Crystal structure of inositol polyphosphate 1-phosphatase INPP1 in complex gadolinium but no lithium at 3 ångström resolution
Analyse Crystal structure of inositol polyphosphate 1-phosphatase INPP1 in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WRO
- Type
- protein
- Length
- 327 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inositol polyphosphate 1-phosphatase
- EC
- 3.1.3.57
- UniProt
- P21327
- Ligands
- GD, SO4
- Pockets
- 4 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inositol polyphosphate 1-phosphatase (EC 3.1.3.57) | protein | 327 | 39% helix, 24% strand | P21327 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 152 | 0.45 | 0.76 | 22 | GD, SO4 |
| 2 | 98 | 0.39 | 0.76 | 20 | empty |
| 3 | 67 | 0.33 | 0.76 | 15 | empty |
| 4 | 52 | 0.31 | 0.76 | 13 | empty |
Compared structures
- 6WRO · Crystal structure of inositol polyphosphate 1-phosphatase INPP1 in complex gadolinium but… · the same entry in another collection · chain A against A, TM-score 1.00
- P21327 · AlphaFold monomer V2.0 prediction for inositol polyphosphate 1-phosphatase (P21327) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21327
- Elsewhere: RCSB PDB 6WRO · PDBe 6WRO · UniProt P21327
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