Research workbench

Eukaryotic LANCL2 protein

Analyse Eukaryotic LANCL2 protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WQ1
Type: protein
Length: 1,583 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lanc-like protein 2
UniProt: Q9NS86
Ligands: ZN
Pockets: 20 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 56% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, D	Lanc-like protein 2	protein	396	55% helix, 2% strand	Q9NS86
C	Lanc-like protein 2	protein	395	56% helix, 2% strand	Q9NS86

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	921	0.76	0.79	74	empty
2	523	0.71	0.80	46	empty
3	80	0.69	0.94	19	empty
4	80	0.69	0.94	19	empty
5	65	0.67	0.94	18	empty

Interfaces

5 interfaces between chains.

B–D · 530 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 500 Å² buried · 3 hydrogen bonds · protein-protein
C–D · 326 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 251 Å² buried · 7 hydrogen bonds · protein-protein
A–B · 84 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6WQ1 · Eukaryotic LanCL2 protein · the same entry in another collection · chain A against A, TM-score 1.00
Q9NS86 · AlphaFold monomer V2.0 prediction for lanc-like protein 2 (Q9NS86) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NS86
Elsewhere: RCSB PDB 6WQ1 · PDBe 6WQ1 · UniProt Q9NS86

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