Research workbench
Structural basis of salicylic acid perception by arabidopsis npr proteins
Analyse Structural basis of salicylic acid perception by arabidopsis npr proteins in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WPG
- Type
- protein
- Length
- 225 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulatory protein NPR4
- UniProt
- Q5ICL9
- Ligands
- SAL
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulatory protein NPR4 | protein | 119 | 70% helix, 0% strand | Q5ICL9 |
| B | Regulatory protein NPR4 | protein | 106 | 80% helix, 0% strand | Q5ICL9 |
Ligands and binding sites
- SAL · 2-hydroxybenzoic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.72 | 0.99 | 16 | SAL |
| 2 | 54 | 0.72 | 0.99 | 16 | SAL |
| 3 | 70 | 0.34 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 965 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6WPG · Structural Basis of Salicylic Acid Perception by Arabidopsis NPR Proteins · the same entry in another collection · chain A against A, TM-score 1.00
- Q5ICL9 · AlphaFold monomer V2.0 prediction for regulatory protein NPR4 (Q5ICL9) · a predicted model of the same protein · chain B against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5ICL9
- Elsewhere: RCSB PDB 6WPG · PDBe 6WPG · UniProt Q5ICL9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.