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Crystal structure of beta sheet heterodimer LHD29

Analyse Crystal structure of beta sheet heterodimer LHD29 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WMK
Type: protein
Length: 258 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta sheet heterodimer LHD29 - chain a; Beta sheet heterodimer LHD29 - chain B
Pockets: 2 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Beta sheet heterodimer LHD29 - chain a	protein	65	51% helix, 28% strand	—
B, D	Beta sheet heterodimer LHD29 - chain B	protein	64	50% helix, 28% strand	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	399	0.60	0.76	37	empty
2	144	0.53	0.80	22	empty

Interfaces

5 interfaces between chains.

A–B · 940 Å² buried · 14 hydrogen bonds · protein-protein
C–D · 910 Å² buried · 15 hydrogen bonds · protein-protein
B–D · 478 Å² buried · 13 hydrogen bonds · protein-protein
A–D · 57 Å² buried · 1 hydrogen bond · protein-protein
B–C · 50 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6WMK · Crystal structure of beta sheet heterodimer LHD29 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6WMK · PDBe 6WMK

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