Research workbench
Human SUN2-KASH4 complex
Analyse Human SUN2-KASH4 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WMD
- Type
- protein
- Length
- 213 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sun domain-containing protein 2; Nesprin-4
- UniProt
- Q9UH99, Q8N205
- Ligands
- MG
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sun domain-containing protein 2 | protein | 196 | 17% helix, 39% strand | Q9UH99 |
| B | Nesprin-4 | protein | 17 | 0% helix, 24% strand | Q8N205 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.50 | 0.87 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 722 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 6WMD · Human Sun2-KASH4 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UH99 · AlphaFold monomer V2.0 prediction for sun domain-containing protein 2 (Q9UH99) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q8N205 · AlphaFold monomer V2.0 prediction for nesprin-4 (Q8N205) · a predicted model of the same protein · chain B against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UH99
- Every structure of UniProt Q8N205
- Elsewhere: RCSB PDB 6WMD · PDBe 6WMD · UniProt Q9UH99 · UniProt Q8N205
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