Research workbench

Proliferation-associated protein 2G4 (PA2G4)

Analyse Proliferation-associated protein 2G4 (PA2G4) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WM8
Type: protein
Length: 1,060 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proliferation-associated protein 2G4
UniProt: Q9UQ80
Ligands: SO4
Pockets: 18 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proliferation-associated protein 2G4	protein	354	34% helix, 25% strand	Q9UQ80
B, C	Proliferation-associated protein 2G4	protein	353	34% helix, 25% strand	Q9UQ80

Ligands and binding sites

SO4 · Sulfate ion · ion · 28 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	500	0.66	0.77	57	empty
2	236	0.63	0.81	26	empty
3	279	0.62	0.80	38	empty
4	277	0.62	0.80	32	SO4
5	367	0.61	0.77	39	empty

Interfaces

3 interfaces between chains.

A–B · 714 Å² buried · 7 hydrogen bonds · protein-protein
A–C · 699 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 684 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6WM8 · Proliferation-Associated protein 2G4 (PA2G4) · the same entry in another collection · chain A against A, TM-score 1.00
Q9UQ80 · AlphaFold monomer V2.0 prediction for proliferation-associated protein 2G4 (Q9UQ80) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UQ80
Elsewhere: RCSB PDB 6WM8 · PDBe 6WM8 · UniProt Q9UQ80

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