Research workbench

Fab fragment of anti-human LAG3 antibody (BAP050)

Analyse Fab fragment of anti-human LAG3 antibody (BAP050) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WKL
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: BAP050 Fab heavy chain; BAP050 Fab light chain
Pockets: 5 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	BAP050 Fab heavy chain	protein	223	10% helix, 49% strand	—
B	BAP050 Fab light chain	protein	213	6% helix, 50% strand	—

Ligands and binding sites

TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.54	0.75	44	empty
2	240	0.52	0.76	37	empty
3	81	0.33	0.74	18	empty
4	84	0.32	0.74	24	empty
5	69	0.32	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 1783 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6WKL · Fab Fragment of Anti-human LAG3 antibody (BAP050) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6WKL · PDBe 6WKL

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.