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Crystal structure of pentalenene synthase mutant F76Y

Analyse Crystal structure of pentalenene synthase mutant F76Y in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WKE
Type: protein
Length: 574 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pentalenene synthase
EC: 4.2.3.7
UniProt: Q55012
Pockets: 4 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pentalenene synthase (EC 4.2.3.7)	protein	268	73% helix, 0% strand	Q55012
B	Pentalenene synthase (EC 4.2.3.7)	protein	306	74% helix, 0% strand	Q55012

Ligands and binding sites

GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1105	0.80	0.82	84	empty
2	518	0.76	0.83	52	empty
3	279	0.65	0.81	36	empty
4	86	0.37	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 945 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6WKE · Crystal structure of pentalenene synthase mutant F76Y · the same entry in another collection · chain A against A, TM-score 1.00
Q55012 · AlphaFold monomer V2.0 prediction for pentalenene synthase (Q55012) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q55012
Elsewhere: RCSB PDB 6WKE · PDBe 6WKE · UniProt Q55012

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