Research workbench
Copper resistance protein copg- form 2
Analyse Copper resistance protein copg- form 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6WJE
- Type
- protein
- Length
- 754 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DUF411 domain-containing protein
- UniProt
- A0A5C0YHL7
- Ligands
- ZN, CU
- Pockets
- 7 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, E, F | DUF411 domain-containing protein | protein | 126 | 25% helix, 35% strand | A0A5C0YHL7 |
| C | DUF411 domain-containing protein | protein | 124 | 25% helix, 35% strand | A0A5C0YHL7 |
Ligands and binding sites
- ZN · Zinc ion · metal · 35 copies · chains A, B, C, D, E, F
- CU · Copper (II) ion · metal · 20 copies · chains A, B, C, D, E, F
- ACT · Acetate ion · additive · 3 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 256 | 0.53 | 0.76 | 28 | ZN |
| 2 | 289 | 0.53 | 0.75 | 36 | ZN |
| 3 | 71 | 0.44 | 0.81 | 22 | empty |
| 4 | 60 | 0.40 | 0.81 | 18 | ACT |
| 5 | 50 | 0.39 | 0.81 | 16 | empty |
Interfaces
5 interfaces between chains.
- B–C · 598 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 585 Ų buried · 15 hydrogen bonds · protein-protein
- E–F · 546 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 524 Ų buried · 14 hydrogen bonds · protein-protein
- B–E · 37 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 2 modified (disulfide, oxidation).
Compared structures
- 6WJE · Copper resistance protein copG- Form 2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A5C0YHL7
- Elsewhere: RCSB PDB 6WJE · PDBe 6WJE · UniProt A0A5C0YHL7
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