Research workbench

KRAS G-quadruplex G16T mutant with bromo uracil replacing T8 and T16.

Analyse KRAS G-quadruplex G16T mutant with bromo uracil replacing T8 and T16. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WCK
Type: DNA
Length: 44 nucleotides
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'-D(*AP*GP*GP*GP*CP*GP*GP*(BRU) P*GP*TP*GP*GP*GP*AP*AP*(BRU)P*AP*GP*GP*GP*AP*A)-3')
Ligands: K
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DNA (5'-D(APGPGPGPCPGPGP(BRU) PGPTPGPGPGPAPAP(BRU)PAPGPGPGPAPA)-3')	dna	22	—	—

Ligands and binding sites

K · Potassium ion · metal · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.37	0.80	11	empty

Interfaces

1 interface between chains.

A–B · 716 Å² buried · 16 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 4 modified (nucleotide modification).

Compared structures

6WCK · KRAS G-quadruplex G16T mutant with Bromo Uracil replacing T8 and T16. · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6WCK · PDBe 6WCK

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.