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Crystal structure of the snare SEC20 bound to DSL1 complex subunit TIP20

Analyse Crystal structure of the snare SEC20 bound to DSL1 complex subunit TIP20 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6WC3
Type: protein
Length: 671 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein transport protein TIP20; Protein transport protein SEC20
UniProt: Q75B58, Q753G8
Pockets: 7 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein transport protein TIP20	protein	577	73% helix, 0% strand	Q75B58
B	Protein transport protein SEC20	protein	94	73% helix, 0% strand	Q753G8

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.73	0.93	19	empty
2	347	0.64	0.79	33	empty
3	71	0.50	0.84	15	empty
4	152	0.41	0.74	18	empty
5	100	0.37	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 1344 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6WC3 · Crystal structure of the SNARE Sec20 bound to Dsl1 complex subunit Tip20 · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q75B58
Every structure of UniProt Q753G8
Elsewhere: RCSB PDB 6WC3 · PDBe 6WC3 · UniProt Q75B58 · UniProt Q753G8

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