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Structure of apo unphosphorylated IRE1

Analyse Structure of apo unphosphorylated IRE1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6W3B
Type: protein
Length: 398 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein KINASE/ENDORIBONUCLEASE IRE1
EC: 2.7.11.1, 3.1.26.-
UniProt: O75460
Pockets: 3 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein KINASE/ENDORIBONUCLEASE IRE1 (EC 2.7.11.1, 3.1.26.-)	protein	398	46% helix, 15% strand	O75460

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	361	0.73	0.84	41	empty
2	214	0.52	0.77	29	empty
3	82	0.45	0.81	17	empty

Compared structures

6W3B · Structure of apo unphosphorylated IRE1 · the same entry in another collection · chain A against A, TM-score 1.00
O75460 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein KINASE/ENDORIBONUCLEASE… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O75460
Elsewhere: RCSB PDB 6W3B · PDBe 6W3B · UniProt O75460

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