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Junction 19, DHR54-DHR79

Analyse Junction 19, DHR54-DHR79 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6W2R
Type: protein
Length: 863 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Junction 19 DHR54-DHR79
Pockets: 5 · best druggability 0.68

Structure

x-ray diffraction · 4 distinct chains · 88% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Junction 19 DHR54-DHR79	protein	218	89% helix, 0% strand	—
B	Junction 19 DHR54-DHR79	protein	221	88% helix, 0% strand	—
C	Junction 19 DHR54-DHR79	protein	213	87% helix, 0% strand	—
D	Junction 19 DHR54-DHR79	protein	211	88% helix, 0% strand	—

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	584	0.68	0.77	45	empty
2	306	0.55	0.75	36	empty
3	60	0.41	0.81	22	empty
4	69	0.41	0.80	23	empty
5	63	0.36	0.78	25	empty

Interfaces

4 interfaces between chains.

A–B · 928 Å² buried · 20 hydrogen bonds · protein-protein
B–D · 229 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 56 Å² buried · 0 hydrogen bonds · protein-protein
C–D · 46 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6W2R · Junction 19, DHR54-DHR79 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6W2R · PDBe 6W2R

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