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Crystal structure of human ppargamma ligand binding domain Y473E mutant

Analyse Crystal structure of human ppargamma ligand binding domain Y473E mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6VZN
Type: protein
Length: 505 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxisome proliferator-activated receptor gamma
UniProt: P37231
Pockets: 6 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 68% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxisome proliferator-activated receptor gamma	protein	254	69% helix, 5% strand	P37231
B	Peroxisome proliferator-activated receptor gamma	protein	251	67% helix, 5% strand	P37231

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	433	0.81	0.88	46	empty
2	315	0.80	0.90	45	empty
3	689	0.68	0.76	81	empty
4	133	0.56	0.83	20	empty
5	74	0.40	0.80	14	empty

Interfaces

1 interface between chains.

A–B · 863 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6VZN · Crystal structure of human PPARgamma ligand binding domain Y473E mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37231
Elsewhere: RCSB PDB 6VZN · PDBe 6VZN · UniProt P37231

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