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Solution structure of human proguanylin

Analyse Solution structure of human proguanylin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1O8R
Type: protein
Length: 94 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Guanylin
UniProt: Q02747
Pockets: 2 · best druggability 0.64

Structure

solution nmr · 1 distinct chain · 24% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Guanylin	protein	94	24% helix, 7% strand	Q02747

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.64	0.94	19	empty
2	59	0.31	0.76	20	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1O8R · Solution structure of human proguanylin · the same entry in another collection · chain A against A, TM-score 1.00
Q02747 · AlphaFold monomer V2.0 prediction for guanylin (Q02747) · a predicted model of the same protein · chain A against A, TM-score 0.60

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q02747
Elsewhere: RCSB PDB 1O8R · PDBe 1O8R · UniProt Q02747

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