Research workbench
The active site of the molybdenum cofactor biosenthetic protein domain CNX1G
Analyse The active site of the molybdenum cofactor biosenthetic protein domain CNX1G in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1O8Q
- Type
- protein
- Length
- 1,272 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Molybdopterin biosynthesis CNX1 protein
- UniProt
- Q39054
- Pockets
- 7 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Molybdopterin biosynthesis CNX1 protein | protein | 159 | 47% helix, 22% strand | Q39054 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1094 | 0.82 | 0.83 | 143 | empty |
| 2 | 1074 | 0.82 | 0.83 | 136 | empty |
| 3 | 134 | 0.65 | 0.88 | 42 | empty |
| 4 | 123 | 0.65 | 0.88 | 41 | empty |
| 5 | 217 | 0.53 | 0.77 | 42 | empty |
Interfaces
10 interfaces between chains.
- A–C · 835 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 834 Ų buried · 7 hydrogen bonds · protein-protein
- D–F · 833 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 829 Ų buried · 7 hydrogen bonds · protein-protein
- E–F · 829 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1O8Q · The active site of the molybdenum cofactor biosenthetic protein domain Cnx1G · the same entry in another collection · chain H against H, TM-score 1.00
- Q39054 · AlphaFold monomer V2.0 prediction for molybdopterin biosynthesis protein CNX1 (Q39054) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q39054
- Elsewhere: RCSB PDB 1O8Q · PDBe 1O8Q · UniProt Q39054
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