Research workbench
Cryo-EM structure of the bbsome-ARL6 complex
Analyse Cryo-EM structure of the bbsome-ARL6 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VOA
- Type
- protein
- Length
- 3,958 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bardet-biedl syndrome 18 protein; Bardet-biedl syndrome 2 protein homolog; Bardet-biedl…
- UniProt
- G3N2W1, Q32L13, Q1JQ97, A6QLF9, F1MB52, F1N4X0, E1BHJ5, Q0IIM2, E1BN34
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 9 distinct chains · 31% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Bardet-biedl syndrome 18 protein | protein | 52 | 37% helix, 2% strand | G3N2W1 |
| B | Bardet-biedl syndrome 2 protein homolog | protein | 619 | 26% helix, 33% strand | Q32L13 |
| E | Bardet-biedl syndrome 4 protein homolog | protein | 388 | 73% helix, 0% strand | Q1JQ97 |
| G | Bardet-biedl syndrome 5 protein homolog | protein | 300 | 14% helix, 30% strand | A6QLF9 |
| C | Bardet-biedl syndrome 7 protein homolog | protein | 667 | 23% helix, 30% strand | F1MB52 |
| F | Tetratricopeptide repeat domain 8 | protein | 475 | 65% helix, 1% strand | F1N4X0 |
| I | Bardet-biedl syndrome 9 | protein | 764 | 25% helix, 32% strand | E1BHJ5 |
| A | ADP-ribosylation factor-like protein 6 | protein | 165 | 10% helix, 7% strand | Q0IIM2 |
| D | BBS1 domain-containing protein | protein | 528 | 10% helix, 15% strand | E1BN34 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1126 | 0.88 | 0.89 | 151 | empty |
| 2 | 1061 | 0.86 | 0.87 | 126 | empty |
| 3 | 813 | 0.85 | 0.87 | 81 | empty |
| 4 | 1089 | 0.83 | 0.84 | 85 | empty |
| 5 | 1041 | 0.80 | 0.82 | 141 | empty |
Interfaces
20 interfaces between chains.
- G–I · 3005 Ų buried · 37 hydrogen bonds · protein-protein
- F–I · 2738 Ų buried · 27 hydrogen bonds · protein-protein
- I–D · 2390 Ų buried · 15 hydrogen bonds · protein-protein
- F–D · 2186 Ų buried · 18 hydrogen bonds · protein-protein
- E–D · 1781 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6VOA · Cryo-EM structure of the BBSome-ARL6 complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q1JQ97 · AlphaFold monomer V2.0 prediction for bardet-biedl syndrome 4 protein homolog (Q1JQ97) · a predicted model of the same protein · chain E against A, TM-score 0.90
- Q0IIM2 · AlphaFold monomer V2.0 prediction for ADP-ribosylation factor-like protein 6 (Q0IIM2) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G3N2W1
- Every structure of UniProt Q32L13
- Every structure of UniProt Q1JQ97
- Every structure of UniProt A6QLF9
- Every structure of UniProt F1MB52
- Every structure of UniProt F1N4X0
- Every structure of UniProt E1BHJ5
- Every structure of UniProt Q0IIM2
- Every structure of UniProt E1BN34
- Elsewhere: RCSB PDB 6VOA · PDBe 6VOA · UniProt G3N2W1 · UniProt Q32L13 · UniProt Q1JQ97 · UniProt A6QLF9 · UniProt F1MB52 · UniProt F1N4X0 · UniProt E1BHJ5 · UniProt Q0IIM2 · UniProt E1BN34
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