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Crystal structure of ip-10 H-form

Analyse Crystal structure of ip-10 H-form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1O80
Type: protein
Length: 145 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small inducible cytokine B10
UniProt: P02778
Pockets: 4 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 22% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Small inducible cytokine B10	protein	74	20% helix, 27% strand	P02778
B	Small inducible cytokine B10	protein	71	24% helix, 25% strand	P02778

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.41	0.82	14	empty
2	82	0.37	0.77	27	empty
3	53	0.36	0.79	17	empty
4	58	0.30	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 947 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1O80 · Crystal structure of IP-10 H-Form · the same entry in another collection · chain B against B, TM-score 1.00
P02778 · AlphaFold monomer V2.0 prediction for C-X-C motif chemokine 10 (P02778) · a predicted model of the same protein · chain B against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02778
Elsewhere: RCSB PDB 1O80 · PDBe 1O80 · UniProt P02778

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