Research workbench
3.10 ångström resolution crystal structure of foldase protein (prsa) from lactococcus lactis
Analyse 3.10 ångström resolution crystal structure of foldase protein (prsa) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VJ2
- Type
- protein
- Length
- 1,080 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Foldase
- EC
- 5.2.1.8
- UniProt
- Q9CEV9
- Pockets
- 11 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 59% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Foldase (EC 5.2.1.8) | protein | 271 | 59% helix, 14% strand | Q9CEV9 |
| B | Foldase (EC 5.2.1.8) | protein | 270 | 59% helix, 14% strand | Q9CEV9 |
| C | Foldase (EC 5.2.1.8) | protein | 269 | 59% helix, 14% strand | Q9CEV9 |
| D | Foldase (EC 5.2.1.8) | protein | 270 | 59% helix, 14% strand | Q9CEV9 |
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 842 | 0.70 | 0.76 | 79 | empty |
| 2 | 797 | 0.67 | 0.74 | 81 | empty |
| 3 | 703 | 0.66 | 0.75 | 76 | empty |
| 4 | 358 | 0.55 | 0.74 | 41 | empty |
| 5 | 207 | 0.54 | 0.78 | 33 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1551 Ų buried · 12 hydrogen bonds · protein-protein
- C–D · 1352 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 697 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 687 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 106 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 modified (engineered).
Compared structures
- 6VJ2 · 3.10 Angstrom Resolution Crystal Structure of Foldase Protein (PrsA) from Lactococcus… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9CEV9 · AlphaFold monomer V2.0 prediction for foldase protein prsa (Q9CEV9) · a predicted model of the same protein · chain D against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9CEV9
- Elsewhere: RCSB PDB 6VJ2 · PDBe 6VJ2 · UniProt Q9CEV9
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