Research workbench

Crystal structure of N-terminal domain of mycobacterium tuberculosis complex lon protease

Analyse Crystal structure of N-terminal domain of mycobacterium tuberculosis complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6VBK
Type: protein
Length: 418 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: LON211
Pockets: 9 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	LON211	protein	208	38% helix, 28% strand	—
B	LON211	protein	210	35% helix, 26% strand	—

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.47	0.81	19	empty
2	139	0.42	0.75	25	empty
3	138	0.41	0.74	25	empty
4	83	0.38	0.77	23	empty
5	104	0.38	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 988 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

6VBK · Crystal structure of N-terminal domain of Mycobacterium tuberculosis complex Lon protease · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6VBK · PDBe 6VBK

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.