Research workbench
Crystal structure of the hybrid C-terminal domain of enzyme I of the bacterial phosphotransferase system formed by hybridizing the scaffold of the thermoanaerobacter tengcongensis enzyme with the active site loops from the escherichia COLI enzyme
Analyse Crystal structure of the hybrid C-terminal domain of enzyme I of the bacterial… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6VBJ
- Type
- protein
- Length
- 626 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoenolpyruvate-protein phosphotransferase
- EC
- 2.7.3.9
- UniProt
- Q8R7R4
- Pockets
- 7 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) | protein | 313 | 52% helix, 13% strand | Q8R7R4 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 115 | 0.59 | 0.86 | 28 | empty |
| 2 | 99 | 0.53 | 0.83 | 26 | empty |
| 3 | 153 | 0.52 | 0.79 | 28 | empty |
| 4 | 180 | 0.46 | 0.75 | 26 | empty |
| 5 | 118 | 0.35 | 0.72 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1932 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
- 6VBJ · Crystal structure of the hybrid C-terminal domain of enzyme I of the bacterial… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R7R4
- Elsewhere: RCSB PDB 6VBJ · PDBe 6VBJ · UniProt Q8R7R4
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