Research workbench
Structures of GCP2 and GCP3 in the native human gamma-tubulin ring complex
Analyse Structures of GCP2 and GCP3 in the native human gamma-tubulin ring complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6V6B
- Type
- protein
- Length
- 1,111 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-tubulin complex component 3; Gamma-tubulin complex component 2
- UniProt
- Q96CW5, Q9BSJ2
- Pockets
- 12 · best druggability 0.72
Structure
electron microscopy · 2 distinct chains · 59% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Gamma-tubulin complex component 3 | protein | 572 | 64% helix, 2% strand | Q96CW5 |
| C | Gamma-tubulin complex component 2 | protein | 539 | 55% helix, 3% strand | Q9BSJ2 |
Pockets
12 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 634 | 0.72 | 0.80 | 70 | empty |
| 2 | 255 | 0.58 | 0.78 | 30 | empty |
| 3 | 70 | 0.52 | 0.85 | 17 | empty |
| 4 | 101 | 0.42 | 0.78 | 19 | empty |
| 5 | 99 | 0.41 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- B–C · 1246 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6V6B · Structures of GCP2 and GCP3 in the native human gamma-tubulin ring complex · the same entry in another collection · chain B against B, TM-score 1.00
- Q96CW5 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 3 (Q96CW5) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q9BSJ2 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex component 2 (Q9BSJ2) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96CW5
- Every structure of UniProt Q9BSJ2
- Elsewhere: RCSB PDB 6V6B · PDBe 6V6B · UniProt Q96CW5 · UniProt Q9BSJ2
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