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Crystal structure of iachsnfr fluorescent acetylcholine sensor precursor binding protein

Analyse Crystal structure of iachsnfr fluorescent acetylcholine sensor precursor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6V1R
Type: protein
Length: 278 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Iachsnfr fluorescent acetylcholine sensor V9 precursor binding protein
Ligands: ACH, SPD
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Iachsnfr fluorescent acetylcholine sensor V9 precursor binding protein	protein	278	47% helix, 17% strand	—

Ligands and binding sites

ACH · Acetylcholine · ligand · chains A
SPD · Spermidine · ligand · chains A
NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · chains A
PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	164	0.76	0.93	31	ACH, SPD
2	55	0.45	0.84	16	empty

Compared structures

6V1R · Crystal structure of iAChSnFR Fluorescent Acetylcholine Sensor precursor binding protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6V1R · PDBe 6V1R

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