Research workbench
Two-pore channel 3
Analyse Two-pore channel 3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6V1Q
- Type
- protein
- Length
- 1,076 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Two pore channel 3
- UniProt
- C4IXV6
- Ligands
- NA
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 1 distinct chain · 63% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Two pore channel 3 | protein | 538 | 63% helix, 0% strand | C4IXV6 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 540 | 0.89 | 0.95 | 37 | NA |
| 2 | 889 | 0.78 | 0.80 | 84 | empty |
| 3 | 1131 | 0.76 | 0.78 | 86 | empty |
| 4 | 977 | 0.73 | 0.77 | 80 | empty |
| 5 | 207 | 0.61 | 0.81 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 4146 Ų buried · 45 hydrogen bonds · protein-protein
Compared structures
- 6V1Q · Two-pore channel 3 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C4IXV6
- Elsewhere: RCSB PDB 6V1Q · PDBe 6V1Q · UniProt C4IXV6
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