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Crystal structure of folylpolyglutamate synthase (TM0166) from thermotoga maritima at 2.10 a resolution

Analyse Crystal structure of folylpolyglutamate synthase (TM0166) from thermotoga… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1O5Z
Type: protein
Length: 421 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Folylpolyglutamate SYNTHASE/DIHYDROFOLATE synthase
UniProt: Q9WY13
Ligands: UNL, SO4, CL
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Folylpolyglutamate SYNTHASE/DIHYDROFOLATE synthase	protein	421	44% helix, 18% strand	Q9WY13

Ligands and binding sites

UNL · Unknown ligand · ligand · 2 copies · chains A
SO4 · Sulfate ion · ion · 4 copies · chains A
CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	839	0.74	0.78	86	SO4, CL, UNL

Compared structures

1O5Z · Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt Q9WY13
Elsewhere: RCSB PDB 1O5Z · PDBe 1O5Z · UniProt Q9WY13

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