Research workbench

3D structure of the LEIOMODIN/TROPOMYOSIN binding interface

Analyse 3D structure of the LEIOMODIN/TROPOMYOSIN binding interface in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6UT2
Type: protein
Length: 106 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leiomodin-2; Tropomyosin alpha-1 chain chimeric peptide
UniProt: Q6P5Q4, P09493

Structure

solution nmr · 2 distinct chains · 68% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leiomodin-2	protein	40	55% helix, 0% strand	Q6P5Q4
B, C	Tropomyosin alpha-1 chain chimeric peptide	protein	33	85% helix, 0% strand	P09493

Interfaces

3 interfaces between chains.

A–B · 764 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 691 Å² buried · 7 hydrogen bonds · protein-protein
A–C · 607 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

6UT2 · 3D structure of the leiomodin/tropomyosin binding interface · the same entry in another collection · chain A against A, TM-score 1.00
P09493 · AlphaFold monomer V2.0 prediction for tropomyosin alpha-1 chain (P09493) · a predicted model of the same protein · chain B against A, TM-score 0.86
Q6P5Q4 · AlphaFold monomer V2.0 prediction for leiomodin-2 (Q6P5Q4) · a predicted model of the same protein · chain A against A, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6P5Q4
Every structure of UniProt P09493
Elsewhere: RCSB PDB 6UT2 · PDBe 6UT2 · UniProt Q6P5Q4 · UniProt P09493

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