Research workbench
Crystal structure of CAB1 pantothenate kinase from saccharomyces cerevisiae
Analyse Crystal structure of CAB1 pantothenate kinase from saccharomyces cerevisiae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UJ5
- Type
- protein
- Length
- 661 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pantothenate kinase CAB1
- EC
- 2.7.1.33
- UniProt
- Q04430
- Ligands
- MG
- Pockets
- 7 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pantothenate kinase CAB1 (EC 2.7.1.33) | protein | 324 | 38% helix, 26% strand | Q04430 |
| B | Pantothenate kinase CAB1 (EC 2.7.1.33) | protein | 337 | 43% helix, 25% strand | Q04430 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 433 | 0.76 | 0.85 | 66 | empty |
| 2 | 550 | 0.73 | 0.81 | 61 | empty |
| 3 | 227 | 0.56 | 0.78 | 36 | empty |
| 4 | 81 | 0.47 | 0.81 | 22 | empty |
| 5 | 94 | 0.35 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2653 Ų buried · 34 hydrogen bonds · protein-protein
Compared structures
- 6UJ5 · Crystal structure of CAB1 Pantothenate Kinase from Saccharomyces cerevisiae · the same entry in another collection · chain A against A, TM-score 1.00
- Q04430 · AlphaFold monomer V2.0 prediction for pantothenate kinase CAB1 (Q04430) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04430
- Elsewhere: RCSB PDB 6UJ5 · PDBe 6UJ5 · UniProt Q04430
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.