Research workbench
Closed-form crystal structure of human ryr receptor 3 ( 848-1055)
Analyse Closed-form crystal structure of human ryr receptor 3 ( 848-1055) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UHE
- Type
- protein
- Length
- 825 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ryanodine receptor 3
- UniProt
- Q15413
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 47% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ryanodine receptor 3 | protein | 207 | 48% helix, 10% strand | Q15413 |
| B | Ryanodine receptor 3 | protein | 204 | 48% helix, 9% strand | Q15413 |
| C | Ryanodine receptor 3 | protein | 208 | 47% helix, 7% strand | Q15413 |
| D | Ryanodine receptor 3 | protein | 206 | 45% helix, 8% strand | Q15413 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 840 | 0.74 | 0.78 | 74 | empty |
| 2 | 603 | 0.72 | 0.80 | 46 | empty |
| 3 | 758 | 0.71 | 0.77 | 60 | empty |
| 4 | 637 | 0.70 | 0.78 | 55 | empty |
| 5 | 125 | 0.39 | 0.74 | 21 | empty |
Interfaces
4 interfaces between chains.
- A–C · 564 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 365 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 362 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 260 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6UHE · Closed-form Crystal Structure of Human RYR Receptor 3 ( 848-1055) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15413
- Elsewhere: RCSB PDB 6UHE · PDBe 6UHE · UniProt Q15413
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