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Co-crystal structure of M. tuberculosis iles T-box in complex with tRNA-3'-2'3'CYCLIC phosphate

Analyse Co-crystal structure of M. tuberculosis iles T-box in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6UFH
Type: RNA
Length: 244 nucleotides
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA (77-mer); RNA (167-mer)
Ligands: MG
Pockets: 5 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	RNA (77-mer)	rna	77	—	—
A	RNA (167-mer)	rna	167	—	—

Ligands and binding sites

MG · Magnesium ion · metal · 6 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	861	0.73	0.78	52	empty
2	671	0.67	0.77	33	empty
3	674	0.66	0.76	51	MG
4	304	0.56	0.77	25	empty
5	82	0.31	0.74	10	empty

Interfaces

1 interface between chains.

B–A · 943 Å² buried · 49 hydrogen bonds · nucleic-nucleic

Modifications

Observed in the structure: 3 modified (nucleotide modification).

Compared structures

6UFH · Co-crystal structure of M. tuberculosis ileS T-box in complex with tRNA-3'-2'3'cyclic… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6UFH · PDBe 6UFH

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