Research workbench
Multi-conformer model of ketosteroid isomerase from pseudomonas putida (pksi) bound to equilenin at 250 K
Analyse Multi-conformer model of ketosteroid isomerase from pseudomonas putida (pksi)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UCN
- Type
- protein
- Length
- 255 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Steroid delta-isomerase
- EC
- 5.3.3.1
- UniProt
- P07445
- Ligands
- EQU, MG, CL
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Steroid delta-isomerase (EC 5.3.3.1) | protein | 126 | 30% helix, 40% strand | P07445 |
| B | Steroid delta-isomerase (EC 5.3.3.1) | protein | 129 | 31% helix, 40% strand | P07445 |
Ligands and binding sites
- EQU · Equilenin · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.65 | 0.85 | 20 | EQU |
| 2 | 258 | 0.65 | 0.81 | 26 | EQU |
| 3 | 79 | 0.34 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1075 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6UCN · Multi-conformer model of Ketosteroid Isomerase from Pseudomonas Putida (pKSI) bound to… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07445
- Elsewhere: RCSB PDB 6UCN · PDBe 6UCN · UniProt P07445
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