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Crystal structure of the metallo-beta-lactamase L1 from stenotrophomonas maltophilia in the complex with hydrolyzed imipnem

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PDB: 6UAF
Type: protein
Length: 267 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative metallo-beta-lactamase L1 (beta-lactamase type II) (ec 3.5.2.6) (penicillinase)
EC: 3.5.2.6
UniProt: B2FTM1
Ligands: HIW, ZN
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative metallo-beta-lactamase L1 (beta-lactamase type II) (ec 3.5.2.6) (penicillinase) (EC 3.5.2.6)	protein	267	31% helix, 23% strand	B2FTM1

Ligands and binding sites

HIW · (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-carboxylic acid · ligand · chains A
ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	131	0.43	0.76	27	HIW, ZN

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6UAF · Crystal Structure of the Metallo-beta-lactamase L1 from Stenotrophomonas maltophilia in… · the same entry in another collection · chain A against A, TM-score 1.00

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Every structure of UniProt B2FTM1
Elsewhere: RCSB PDB 6UAF · PDBe 6UAF · UniProt B2FTM1

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