Research workbench
Structure of T. brucei MERS1-RNA complex
Analyse Structure of T. brucei MERS1-RNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6U9X
- Type
- protein + RNA
- Length
- 596 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial edited mRNA stability factor 1; RNA…
- UniProt
- B6SBM0
- Pockets
- 6 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 33% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Mitochondrial edited mRNA stability factor 1 | protein | 294 | 33% helix, 23% strand | B6SBM0 |
| A | Mitochondrial edited mRNA stability factor 1 | protein | 294 | 34% helix, 24% strand | B6SBM0 |
| H, K | RNA (5'-R(*GP*AP*GP*AP*GP*GP*GP*GP*GP*UP*U)-3') | rna | 4 | — | — |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 738 | 0.68 | 0.76 | 62 | empty |
| 2 | 118 | 0.43 | 0.77 | 15 | empty |
| 3 | 92 | 0.42 | 0.79 | 14 | empty |
| 4 | 124 | 0.39 | 0.74 | 22 | empty |
| 5 | 120 | 0.36 | 0.73 | 19 | empty |
Interfaces
3 interfaces between chains.
- D–H · 1128 Ų buried · 38 hydrogen bonds · protein-nucleic
- A–K · 1111 Ų buried · 34 hydrogen bonds · protein-nucleic
- D–A · 661 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6U9X · Structure of T. brucei MERS1-RNA complex · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6SBM0
- Elsewhere: RCSB PDB 6U9X · PDBe 6U9X · UniProt B6SBM0
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