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Structure of GM9_TH8SEQ732127 Fab

Analyse Structure of GM9_TH8SEQ732127 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6U9U
Type: protein
Length: 430 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GM9_TH8SEQ732127 Fab heavy chain; GM9_TH8SEQ732127 Fab light chain
Ligands: NA
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	GM9_TH8SEQ732127 Fab heavy chain	protein	218	6% helix, 55% strand	—
L	GM9_TH8SEQ732127 Fab light chain	protein	212	6% helix, 52% strand	—

Ligands and binding sites

NA · Sodium ion · metal · 6 copies · chains H, L
FMT · Formic acid · additive · 2 copies · chains H, L
EDO · 1,2-ethanediol · additive · 2 copies · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	525	0.59	0.73	56	FMT
2	94	0.33	0.73	25	NA
3	52	0.26	0.74	17	EDO

Interfaces

1 interface between chains.

H–L · 1768 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6U9U · Structure of GM9_TH8seq732127 FAB · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6U9U · PDBe 6U9U

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