Research workbench

BRD2-BD2 in complex with the cyclic peptide 3.1_3

Analyse BRD2-BD2 in complex with the cyclic peptide 3.1_3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6U71
Type: protein
Length: 121 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bromodomain-containing protein 2; Cyclic peptide 3.1_3
UniProt: P25440
Ligands: ACE, NH2

Structure

x-ray diffraction · 2 distinct chains · 63% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bromodomain-containing protein 2	protein	110	69% helix, 0% strand	P25440
B	Cyclic peptide 3.1_3	protein	11	0% helix, 45% strand	—

Ligands and binding sites

ACE · Acetyl group · ligand · chains A, B
NH2 · Amino group · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 516 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent, 2 modified (covalent ligand, acetylation).

Compared structures

6U71 · BRD2-BD2 in complex with the cyclic peptide 3.1_3 · the same entry in another collection · chain A against A, TM-score 1.00
P25440 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 2 (P25440) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25440
Elsewhere: RCSB PDB 6U71 · PDBe 6U71 · UniProt P25440

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