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Cryo-EM structure of E. COLI lona S679A

Analyse Cryo-EM structure of E. COLI lona S679A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6U5Z
Type: protein
Length: 3,174 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lon protease
EC: 3.4.21.53
UniProt: C3TLS2
Pockets: 20 · best druggability 0.74

Structure

electron microscopy · 1 distinct chain · 40% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Lon protease (EC 3.4.21.53)	protein	529	40% helix, 15% strand	C3TLS2

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	830	0.74	0.78	79	empty
2	836	0.73	0.78	83	empty
3	1143	0.72	0.76	91	empty
4	769	0.72	0.78	68	empty
5	1184	0.71	0.75	86	empty

Interfaces

5 interfaces between chains.

D–E · 1702 Å² buried · 11 hydrogen bonds · protein-protein
E–F · 1661 Å² buried · 8 hydrogen bonds · protein-protein
C–D · 1617 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 1614 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 1531 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

6U5Z · Cryo-EM structure of E. coli LonA S679A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C3TLS2
Elsewhere: RCSB PDB 6U5Z · PDBe 6U5Z · UniProt C3TLS2

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