Research workbench

Solution structure of paxillin LIM4 in complex with kindlin-2 F0

Analyse Solution structure of paxillin LIM4 in complex with kindlin-2 F0 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6U4N
Type: protein
Length: 159 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fermitin family homolog 2; Paxillin
UniProt: Q96AC1, P49023
Ligands: ZN

Structure

solution nmr · 2 distinct chains · 14% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fermitin family homolog 2	protein	94	17% helix, 19% strand	Q96AC1
B	Paxillin	protein	65	11% helix, 22% strand	P49023

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 548 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

6U4N · Solution structure of paxillin LIM4 in complex with kindlin-2 F0 · the same entry in another collection · chain A against A, TM-score 1.00
Q96AC1 · AlphaFold monomer V2.0 prediction for fermitin family homolog 2 (Q96AC1) · a predicted model of the same protein · chain A against A, TM-score 0.79
P49023 · AlphaFold monomer V2.0 prediction for paxillin (P49023) · a predicted model of the same protein · chain B against A, TM-score 0.58

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96AC1
Every structure of UniProt P49023
Elsewhere: RCSB PDB 6U4N · PDBe 6U4N · UniProt Q96AC1 · UniProt P49023

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