Research workbench
Structure of the vesicular stomatitis virus L protein in complex with its phosphoprotein cofactor (3.0 a resolution)
Analyse Structure of the vesicular stomatitis virus L protein in complex with its… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6U1X
- Type
- protein
- Length
- 2,087 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L; Phosphoprotein
- EC
- 2.7.7.48, 2.1.1.56, 2.7.7.88, 2.1.1.296
- UniProt
- P03523, P03520
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 44% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase L (EC 2.7.7.48, 2.1.1.56, 2.7.7.88, 2.1.1.296) | protein | 2059 | 45% helix, 9% strand | P03523 |
| P | Phosphoprotein | protein | 28 | 0% helix, 4% strand | P03520 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1078 | 0.83 | 0.84 | 118 | empty |
| 2 | 599 | 0.79 | 0.85 | 75 | empty |
| 3 | 1195 | 0.77 | 0.79 | 110 | empty |
| 4 | 510 | 0.73 | 0.82 | 48 | empty |
| 5 | 288 | 0.72 | 0.85 | 33 | empty |
Interfaces
1 interface between chains.
- A–P · 1754 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6U1X · Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03523
- Every structure of UniProt P03520
- Elsewhere: RCSB PDB 6U1X · PDBe 6U1X · UniProt P03523 · UniProt P03520
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.