Research workbench
Cryo-EM structure of a de novo designed 16-helix transmembrane nanopore, TMHC8_R.
Analyse Cryo-EM structure of a de novo designed 16-helix transmembrane nanopore… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6U1S
- Type
- protein
- Length
- 2,480 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- De novo designed 16-helix transmembrane nanopore, TMHC8_R
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 1 distinct chain · 89% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, F, H, J, L, N | De novo designed 16-helix transmembrane nanopore, TMHC8_R | protein | 310 | 89% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 848 | 0.76 | 0.80 | 95 | empty |
| 2 | 778 | 0.76 | 0.81 | 88 | empty |
| 3 | 843 | 0.75 | 0.79 | 92 | empty |
| 4 | 824 | 0.75 | 0.79 | 88 | empty |
| 5 | 827 | 0.75 | 0.79 | 82 | empty |
Interfaces
8 interfaces between chains.
- A–N · 2863 Ų buried · 30 hydrogen bonds · protein-protein
- J–L · 2862 Ų buried · 30 hydrogen bonds · protein-protein
- F–H · 2858 Ų buried · 30 hydrogen bonds · protein-protein
- D–F · 2858 Ų buried · 30 hydrogen bonds · protein-protein
- H–J · 2856 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 6U1S · Cryo-EM structure of a de novo designed 16-helix transmembrane nanopore, TMHC8_R. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6U1S · PDBe 6U1S
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