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In situ structure of bmcpv RNA-dependent RNA polymerase at abortive state

Analyse In situ structure of bmcpv RNA-dependent RNA polymerase at abortive state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TZ0
Type: protein
Length: 1,709 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA polymerase; Viral structural protein 4
EC: 2.7.7.48
UniProt: Q993A4, Q9IR43
Pockets: 20 · best druggability 0.83

Structure

electron microscopy · 2 distinct chains · 42% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-dependent RNA polymerase (EC 2.7.7.48)	protein	1208	43% helix, 14% strand	Q993A4
B	Viral structural protein 4	protein	501	40% helix, 14% strand	Q9IR43

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1086	0.83	0.84	99	empty
2	156	0.80	0.96	31	empty
3	93	0.76	0.97	26	empty
4	1060	0.74	0.77	99	empty
5	539	0.73	0.81	62	empty

Interfaces

1 interface between chains.

A–B · 3729 Å² buried · 41 hydrogen bonds · protein-protein

Compared structures

6TZ0 · In situ structure of BmCPV RNA-dependent RNA polymerase at abortive state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q993A4
Every structure of UniProt Q9IR43
Elsewhere: RCSB PDB 6TZ0 · PDBe 6TZ0 · UniProt Q993A4 · UniProt Q9IR43

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