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Human xpg-DNA, complex 1

Analyse Human xpg-DNA, complex 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
6TUW
Type
protein + DNA
Length
331 residues
Chains
3
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
DNA repair protein complementing xp-G CELLS,DNA repair protein complementing xp-G cells…
EC
3.1.-.-
UniProt
P28715
Pockets
3 · best druggability 0.73

Structure

x-ray diffraction · 3 distinct chains · 51% helix, 10% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ADNA repair protein complementing xp-G CELLS,DNA repair protein complementing xp-G cells (EC 3.1.-.-)protein31351% helix, 10% strandP28715
BDNA (5'-D(P*TP*GP*CP*AP*GP*AP*GP*TP*TP*C)-3')dna10——
CDNA (5'-D(P*GP*AP*AP*CP*TP*CP*TP*G)-3')dna8——

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
19540.730.7777empty
21430.480.7822empty
31750.450.7516empty

Interfaces

3 interfaces between chains.

  • B–C · 394 Ų buried · 35 hydrogen bonds · nucleic-nucleic
  • A–B · 199 Ų buried · 1 hydrogen bond · protein-nucleic
  • A–C · 165 Ų buried · 2 hydrogen bonds · protein-nucleic

Compared structures

  • 6TUW · human XPG-DNA, Complex 1 · the same entry in another collection · chain A against A, TM-score 1.00
  • P28715 · AlphaFold monomer V2.0 prediction for DNA repair protein complementing xp-G cells (P28715) · a predicted model of the same protein · chain A against A, TM-score 0.93

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